WELCOME TO THE MCLENDON LAB!
This lab was created by Jared McLendon, the assistant Professor of Pharmaceutical Sciences and Experimental Therapeutics in order to further understand the post-transactional gene regulation and create RNA based therapies for disease. Take a look at his CV here to know more about his work and accomplishments.
WHAT WE STUDY AND DO
We are investigating molecular mechanisms enabling mechanical regulation of RNA and protein expression is vascular cells. Specifically, identifying Sorbs 2 dependent mechanisms of cytoskeletal remodeling and mechanical signaling in Alzheimer's and vascular disease.
OUR GOALS
Our current goals focuses on Alzheimer's and vascular diseases.
For Alzheimer's we want to investigate if neural loss of Sorbs 2 accelerates ADRD neurodegeneration and atherosclerosis.
For vascular disease we want to identify how Sorbs 2 participates in mechanical signaling pathways that remodel actin and microtubule networks and see if Sorbs 2 is required for smooth muscle contraction or vascular disease phenotype in mice.
OUR SUPPORT
We are extremely thankful for the support given to us by the American Heart Association and the Alzheimer's Association Research Fellowship Program to help us continue to develop our research.
COME JOIN US!
We are open to everyone! Whether you are an undergrad, graduate, or post graduate, as long as you are motivated and want to investigate something you are interested in, our lab is a great way to do so. Please contact us at PSET-MclendonLab@uiowa.edu